Central and peripheral adiposity and premenopausal breast cancer risk: a pooled analysis of 440,179 women

MJ Schoemaker; T Ellington; HB Nichols; LB Wright; ME Jones; KM O’Brien; CR Weinberg; HO Adami; L Baglietto; KA Bertrand; Y Chen; J Clague DeHart; AH Eliassen; GG Giles; SC Houghton; VA Kirsh; RL Milne; JR Palmer; HL Park; TE Rohan; G Severi; XO Shu; RM Tamimi; LJ Vatten; E Weiderpass; WC Willett; A Zeleniuch-Jacquotte; W Zheng; DP Sandler; AJ Swerdlow

Journal article

Central and peripheral adiposity and premenopausal breast cancer risk: a pooled analysis of 440,179 women

MJ Schoemaker, T Ellington, HB Nichols, LB Wright, ME Jones, KM O’Brien, CR Weinberg, HO Adami, L Baglietto, KA Bertrand, Y Chen, J Clague DeHart, AH Eliassen, GG Giles, SC Houghton, VA Kirsh, RL Milne, JR Palmer, HL Park, TE Rohan Show all

Breast Cancer Research | BMC | Published : 2025

DOI: 10.1186/s13058-025-01995-x

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Abstract

Background: Among premenopausal women, higher body mass index (BMI) is associated with lower breast cancer risk, although the underlying mechanisms are unclear. Investigating adiposity distribution may help clarify impacts on breast cancer risk. This study was initiated to investigate associations of central and peripheral adiposity with premenopausal breast cancer risk overall and by other risk factors and breast cancer characteristics. Methods: We used individual-level data from 14 prospective cohort studies to estimate hazard ratios (HRs) for premenopausal breast cancer using Cox proportional hazards regression. Analyses included 440,179 women followed for a median of 7.5 years (interquar..

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